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Article

Tec kinase migrates to the T cell-APC interface independently of its pleckstrin homology domain.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2004

Garçon Fabien, Bismuth Georges, Isnardon Daniel, Olive Daniel, Nunès Jacques A

Abstract excerpt

Tec is the prototypical member of the Tec tyrosine kinases family, which plays an important role in T cell signaling. We show in this study that Tec translocates to the immunological synapse when a T cell contacts a dendritic cell. Surprisingly, the presence of the pleckstrin homology (PH) domain of Tec is not required for this accumulation, and despite a strong activation of 3'-phosphorylated phosphoinositide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15240663
DOI: 10.4049/jimmunol.173.2.770

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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