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Article

Selective defect in antigen-induced TCR internalization at the immune synapse of CD8 T cells bearing the ZAP-70(Y292F) mutation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2005

Davanture Suzel, Leignadier Julie, Milani Pascale, Soubeyran Philippe, Malissen Bernard, Malissen Marie, Schmitt-Verhulst Anne-Marie, Boyer Claude

Abstract excerpt

Cbl proteins have been implicated in ligand-induced TCR/CD3 down-modulation, but underlying mechanisms are unclear. We analyzed the effect of mutation of a cbl-binding site on ZAP-70 (ZAP-Y292F) on dynamics, internalization, and degradation of the TCR/CD3 complex in response to distinct stimuli. Naive CD8 T cells expressing the P14 transgenic TCR from ZAP-Y292F mice were selectively affected in TCR/CD3...

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PMID: 16116204
DOI: 10.4049/jimmunol.175.5.3140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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