Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes.

doi:10.1002/(SICI)1521-4141(199808)28:08<2320::AID-IMMU2320>3.0.CO;2-K

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Article

Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes.

European journal of immunology - 1 Aug 1998

Avraham A, Jung S, Samuels Y, Seger R, Ben-Neriah Y

Abstract excerpt

Previously we implicated c-Jun N-terminal kinase (JNK) as an element that is involved in signal integration during co-stimulation of T lymphocytes. This pathway has now been traced to an upper level, comprising MAPKK SEK1/MKK4/JNKK1 which, similarly to JNK, must receive input both from the TCR an...

Topics

Animals
Calcineurin
Calcium-Calmodulin-Dependent Protein Kinases
Cell Cycle Proteins
Enzyme Activation
GTP-Binding Proteins
Humans
Isoenzymes
JNK Mitogen-Activated Protein Kinases
Jurkat Cells
Lymphocyte Activation
MAP Kinase Kinase 4
Mice
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases
Mutation
Protein Kinase C
Protein Kinase C-theta

Source

Open in PubMed

Identifiers

PMID: 9710210
DOI: 10.1002/(SICI)1521-4141(199808)28:08<2320::AID-IMMU2320>3.0.CO;2-K

Genes

CDC42

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9710210-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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