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Article

SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase.

The Journal of biological chemistry - 31 Dec 2004

Tomlinson Michael G, Heath Victoria L, Turck Chris W, Watson Steve P, Weiss Arthur

Abstract excerpt

The Tec family of protein-tyrosine kinases (PTKs), that includes Tec, Itk, Btk, Bmx, and Txk, plays an essential role in phospholipase Cgamma (PLCgamma) activation following antigen receptor stimulation. This function requires activation of phosphatidylinositol 3-kinase (PI 3-kinase), which promotes Tec membrane localization through phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P(3)) generation. The...

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PMID: 15492005
DOI: 10.1074/jbc.M408141200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase.PMID 15492005Read ↗

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