Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling.

doi:10.1038/369327a0

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling.

Nature - 26 May 1994

Pagès F, Ragueneau M, Rottapel R, Truneh A, Nunes J, Imbert J, Olive D

Abstract excerpt

The engagement of CD28 with its ligand B7.1/CD80 results in potent costimulation of T-cell activation initiated through the CD3/T-cell receptor complex. The biochemical basis of CD28 costimulatory function is poorly understood. The signalling pathways used by CD28 are unlike those used by the CD3...

Topics

Animals
CD28 Antigens
Humans
Hybridomas
Immunoblotting
L Cells
Mice
Mutation
Phosphatidylinositol 3-Kinases
Phosphorylation
Phosphotransferases (Alcohol Group Acceptor)
Precipitin Tests
Protein Binding
Recombinant Fusion Proteins
Signal Transduction
T-Lymphocytes
Transfection

Source

Open in PubMed

Identifiers

PMID: 8183372
DOI: 10.1038/369327a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8183372-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics