Article
Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism.
The Journal of cell biology - 23 Feb 1998
Lowin-Kropf B, Shapiro V S, Weiss A
Abstract excerpt
Binding of a T cell to an appropriate antigen-presenting cell (APC) induces the rapid reorientation of the T cell cytoskeleton and secretory apparatus towards the cell-cell contact site in a T cell antigen receptor (TCR) and peptide/major histocompatibility complex-dependent process. Such T cell...
Topics
- Actins
- Antibodies
- Binding Sites
- CD3 Complex
- Centrosome
- Cytoskeleton
- Fluorescence Polarization Immunoassay
- Gene Expression
- Gene Expression Regulation
- Genes, Dominant
- Genes, ras
- Humans
- Jurkat Cells
- Membrane Proteins
- Microspheres
- Mutation
- Phosphorylation
- Protein-Tyrosine Kinases