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Article

Differential Effects of Culture on Imprinted H19 Expression in the Preimplantation Mouse Embryo1

1 Jun 2000

Abstract excerpt

The H19 gene is imprinted with preferential expression from the maternal allele. The putative imprinting control region for this locus is hypermethylated on the repressed paternal allele. Although maternal-specific expression of H19 is observed in mouse blastocysts that develop in vivo, biallelic expression has been documented in embryos and embryonic stem cells experimentally manipulated by in vitro culture...

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Share to Epigenetics and DNA Methylation
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PMID: 10819752
DOI: 10.1095/biolreprod62.6.1526

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