Article
The CHEK2*1100delC variant acts as a breast cancer risk modifier in non-BRCA1/BRCA2 multiple-case families.
Cancer research - 1 Dec 2003
Oldenburg Rogier A, Kroeze-Jansema Karin, Kraan Jaennelle, Morreau Hans, Klijn Jan G M, Hoogerbrugge Nicoline, Ligtenberg Marjolein J L, van Asperen Christi J, Vasen Hans F A, Meijers Carel, Meijers-Heijboer Hanne, de Bock Truuske H, Cornelisse Cees J, Devilee Peter
Abstract excerpt
The frame-shifting mutation 1100delC in the cell-cycle-checkpoint kinase 2 gene (CHEK2) has been reported to be associated with familial breast cancer in families in which mutations in BRCA1 and BRCA2 were excluded. To investigate the role of this variant as a candidate breast cancer susceptibility allele, we determined its prevalence in 237 breast cancer patients and 331 healthy relatives derived from 71...
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