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Article

CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumours.

British journal of cancer - 2 Dec 2002

Sodha N, Bullock S, Taylor R, Mitchell G, Guertl-Lackner B, Williams R D, Bevan S, Bishop K, McGuire S, Houlston R S, Eeles R A

Abstract excerpt

We have recently shown that the CHEK2*1100delC mutation acts as a low penetrance breast cancer susceptibility allele. To investigate if other CHEK2 variants confer an increased risk of breast cancer, we have screened an affected individual with breast cancer from 68 breast cancer families. Five o...

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Source

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Identifiers

PMID: 12454775
DOI: 10.1038/sj.bjc.6600637
PMCID: PMC2376278

Genes

CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12454775-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumours.PMID 12454775Read ↗

Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts.Semantic proximity Read ↗

The CHEK2*1100delC variant acts as a breast cancer risk modifier in non-BRCA1/BRCA2 multiple-case families.Semantic proximity Read ↗

Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility.Semantic proximity Read ↗

Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals.Semantic proximity Read ↗

Limited relevance of the CHEK2 gene in hereditary breast cancer.Semantic proximity Read ↗

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.Semantic proximity Read ↗

Breast Cancer Survival and Tumor Characteristics in Premenopausal Women Carrying the <i>CHEK2*1100delC</i> Germline MutationSemantic proximity Read ↗

The CHEK2 gene and inherited breast cancer susceptibility.Semantic proximity Read ↗

Correlation of CHEK2 protein expression and c.1100delC mutation status with tumor characteristics among unselected breast cancer patientsSemantic proximity Read ↗

A search for modifying genetic factors in CHEK2:c.1100delC breast cancer patients.Semantic proximity Read ↗

Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women.Semantic proximity Read ↗

Linkage disequilibrium mapping of CHEK2: common variation and breast cancer risk.Semantic proximity Read ↗

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