Article
Strain-specific variants of the mouse Cftr promoter region reveal transcriptional regulatory elements.
Human molecular genetics - 1 Sept 2004
Ulatowski Lynn M, Whitmore Kirstin L, Romigh Todd, VanderWyden Annalisa S, Satinover Shama M, Drumm Mitchell L
Abstract excerpt
Regulation of cystic fibrosis transmembrane conductance regulator (CFTR) mRNA levels is not well understood. Mouse Cftr mRNA shows strain-dependent expression differences that cannot be fully explained by variation at non-Cftr loci. Differences in tracheal and colonic expression appear to be due predominantly to elements linked to Cftr. Fifteen single nucleotide sequence variations were found within 1.4 kb 5' to...
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