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Article

The cystic fibrosis gene has a “housekeeping”-type promoter and is expressed at low levels in cells of epithelial origin

1 May 1991

Abstract excerpt

Evaluation of the expression of the cystic fibrosis (CF) gene in human epithelial cell lines demonstrated active, but low level, transcription of the gene. Analysis of 3.8 kilobases of genomic sequences 5' to exon 1 of the CF gene demonstrated no TATA promoter element, but a high G + C content, multiple transcription start sites, and several potential Sp1 binding sites. Fragments of 5'-flanking sequences from 2.2...

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PMID: 1709163
DOI: 10.1016/s0021-9258(18)31562-x

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