Article
Spontaneous rescue from cystic fibrosis in a mouse model.
BMC genetics - 29 Mar 2006
Charizopoulou Nikoletta, Wilke Martina, Dorsch Martina, Bot Alice, Jorna Huub, Jansen Silke, Stanke Frauke, Hedrich Hans J, de Jonge Hugo R, Tümmler Burkhard
Abstract excerpt
BACKGROUND: From the original CftrTgH(neoim)Hgu mutant mouse model with a divergent genetic background (129P2, C57BL/6, MF1) we have generated two inbred CftrTgH(neoim)Hgu mutant strains named CF/1-CftrTgH(neoim)Hgu and CF/3-CftrTgH(neoim)Hgu, which are fertile and show normal growth and lifespan. Initial genome wide scan analysis with microsatellite markers indicated that the two inbred strains differed on the...
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