A potential animal model for studying CF heterozygote advantage: genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice.

doi:10.1016/0885-4505(92)90011-m

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Article

A potential animal model for studying CF heterozygote advantage: genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice.

Biochemical medicine and metabolic biology - 1 Feb 1992

Sweet A, Erickson R P, Huntington C, Dawson D

Abstract excerpt

We have used Ussing chambers to measure chloride secretion by colonic segments (mucosa, muscularis, and serosa) from various inbred strains of mice. We found lower theophylline-induced Cl- secretion in the DBA/2J than in the C57BL/6J strain. Their F1 showed significantly higher levels of Cl- secr...

Topics

Animals
Chlorides
Colon
Cystic Fibrosis
Disease Models, Animal
Electric Conductivity
Female
Genetic Variation
Heterozygote
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-met
Theophylline

Source

Open in PubMed

Identifiers

PMID: 1562359
DOI: 10.1016/0885-4505(92)90011-m

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1562359-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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