Article
Detection of modifier loci influencing the lung phenotype of cystic fibrosis knockout mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Nov 2002
Haston Christina K, McKerlie Colin, Newbigging Susan, Corey Mary, Rozmahel Richard, Tsui Lap-Chee
Abstract excerpt
The variable severity of lung disease associated with cystic fibrosis (CF) cannot be explained by the genotype of the cystic fibrosis transmembrane conductance regulator (CFTR) locus alone. Lung disease has been reported in a congenic CF mouse model of C57BL/6J genetic background (B6 CF), in the absence of detectable infection, but not in CF mice of mixed genetic background, nor in wild-type animals maintained in...
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