Article
Variation in airway responsiveness of male C57BL/6 mice from 5 vendors.
Journal of the American Association for Laboratory Animal Science : JAALAS - 1 Jul 2012
Chang Herng-Yu Sucie, Mitzner Wayne, Watson Julie
Abstract excerpt
Mice are now the most commonly used animal model for the study of asthma. The mouse asthma model has many characteristics of the human pathology, including allergic sensitization and airway hyperresponsiveness. Inbred strains are commonly used to avoid variations due to genetic background, but variations due to rearing environment are not as well recognized. After a change in mouse vendors and a switch from...
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