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Article

Association between serum paraoxonase (PON1) gene promoter T(-107)C polymorphism, PON1 activity and HDL levels in healthy Sicilian octogenarians.

Experimental gerontology - 1 Jul 2004

Campo Salvatore, Sardo Maria A, Trimarchi Giuseppe, Bonaiuto Michele, Fontana Luisa, Castaldo Maria, Bonaiuto Antonio, Saitta Carlo, Bitto Alessandra, Manduca Bruno, Riggio Stefania, Saitta Antonino

Abstract excerpt

Age is associated with an enhanced low density lipoprotein (LDL) oxidation and atherosclerosis, thus, subjects over 80 years without cardiovascular disease provide a model to investigate the protective factors against atherosclerosis. Serum paraoxonase (PON1), an high density lipoprotein (HDL)-bound enzyme, prevents LDL oxidation. The aim of the present study was to evaluate the contribution of the PON1 promoter...

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Share to Aged
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aryldialkylphosphatase

Share to Cholesterol, HDL

Share to Genotype

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 15236768
DOI: 10.1016/j.exger.2004.03.017

Genes

PON1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association between serum paraoxonase (PON1) gene promoter T(-107)C polymorphism, PON1 activity and HDL levels in healthy Sicilian octogenarians.PMID 15236768Read ↗

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