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Article

Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.

The Journal of biological chemistry - 10 Sept 2004

Cerosaletti Karen, Concannon Patrick

Abstract excerpt

The Atm protein kinase and Mre11-Rad50-nibrin (MRN) complex play an integral role in the cellular response to DNA double-strand breaks. Mutations in Mre11 and nibrin result in the radiosensitivity disorders ataxia-telangiectasia-like disorder (ATLD) and Nijmegen breakage syndrome (NBS), respectively. Cells from ATLD and NBS patients are deficient in activation of the Atm protein kinase and phosphorylation of...

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Identifiers

PMID: 15234984
DOI: 10.1074/jbc.M404294200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.PMID 15234984Read ↗

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Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair.Semantic proximity Read ↗

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.Semantic proximity Read ↗

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.Semantic proximity Read ↗

Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1.Semantic proximity Read ↗

Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation.Semantic proximity Read ↗

Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.Semantic proximity Read ↗

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.Semantic proximity Read ↗

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