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Article

ATM-dependent phosphorylation of nibrin in response to radiation exposure.

Nature genetics - 1 May 2000

Gatei M, Young D, Cerosaletti K M, Desai-Mehta A, Spring K, Kozlov S, Lavin M F, Gatti R A, Concannon P, Khanna K

Abstract excerpt

Mutations in the gene ATM are responsible for the genetic disorder ataxia-telangiectasia (A-T), which is characterized by cerebellar dysfunction, radiosensitivity, chromosomal instability and cancer predisposition. Both the A-T phenotype and the similarity of the ATM protein to other DNA-damage sensors suggests a role for ATM in biochemical pathways involved in the recognition, signalling and repair of DNA...

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Source

Identifiers

PMID: 10802669
DOI: 10.1038/75508

Genes

ATM
MRE11
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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