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Article

Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation.

The Journal of biological chemistry - 13 Jun 2003

Cerosaletti Karen M, Concannon Patrick

Abstract excerpt

The Mre11.Rad50.nibrin protein complex plays an essential role in the mammalian cellular response to DNA double-strand breaks. The disorder Nijmegen breakage syndrome (NBS) results from mutations in the NBS1 gene that encodes nibrin, and NBS cells are radiosensitive and defective in S-phase check...

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Identifiers

PMID: 12679336
DOI: 10.1074/jbc.M211689200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12679336-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation.PMID 12679336Read ↗

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A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin.Semantic proximity Read ↗

Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation.Semantic proximity Read ↗

ATM-dependent phosphorylation of nibrin in response to radiation exposure.Semantic proximity Read ↗

The Nijmegen Breakage Syndrome Protein Is Essential for Mre11 Phosphorylation upon DNA DamageSemantic proximity Read ↗

The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity.Semantic proximity Read ↗

NFBD1, a Novel Nuclear Protein with Signature Motifs of FHA and BRCT, and an Internal 41-Amino Acid Repeat Sequence, Is an Early Participant in DNA Damage ResponseSemantic proximity Read ↗

NBS1 and its functional role in the DNA damage response.Semantic proximity Read ↗

Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.Semantic proximity Read ↗

Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.Semantic proximity Read ↗

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break RepairSemantic proximity Read ↗

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