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Article

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.

Nature - 10 May 2007

Stracker Travis H, Morales Monica, Couto Suzana S, Hussein Hussein, Petrini John H J

Abstract excerpt

The MRE11 complex (MRE11, RAD50 and NBS1) and the ataxia-telangiectasia mutated (ATM) kinase function in the same DNA damage response pathway to effect cell cycle checkpoint activation and apoptosis. The functional interaction between the MRE11 complex and ATM has been proposed to require a conserved C-terminal domain of NBS1 for recruitment of ATM to sites of DNA damage. Human Nijmegen breakage syndrome (NBS)...

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Share to Acid Anhydride Hydrolases
Share to Ataxia Telangiectasia Mutated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BH3 Interacting Domain Death Agonist Protein

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Source

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Identifiers

PMID: 17429352
DOI: 10.1038/nature05740
PMCID: PMC3089978

Genes

ATM
MRE11
BID
RAD50

Provenance

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.PMID 17429352Read ↗

A murine model of Nijmegen breakage syndrome.Semantic proximity Read ↗

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosisSemantic proximity Read ↗

Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.Semantic proximity Read ↗

The NBS1-ATM Connection RevisitedSemantic proximity Read ↗

NBS1 and its functional role in the DNA damage response.Semantic proximity Read ↗

The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.Semantic proximity Read ↗

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.Semantic proximity Read ↗

Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS.Semantic proximity Read ↗

Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1.Semantic proximity Read ↗

Functional Interaction of H2AX, NBS1, and p53 in ATM-Dependent DNA Damage Responses and Tumor SuppressionSemantic proximity Read ↗

Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functionsSemantic proximity Read ↗

Nbs1 Mediates Assembly and Activity of the Mre11 complexSemantic proximity Read ↗

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