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Article

Nuclear export of NBN is required for normal cellular responses to radiation.

Molecular and cellular biology - 1 Feb 2009

Vissinga Christine S, Yeo Tiong C, Warren Sarah, Brawley James V, Phillips Jennifer, Cerosaletti Karen, Concannon Patrick

Abstract excerpt

Nijmegen breakage syndrome arises from hypomorphic mutations in the NBN gene encoding nibrin, a component of the MRE11/RAD50/nibrin (MRN) complex. In mammalian cells, the MRN complex localizes to the nucleus, where it plays multiple roles in the cellular response to DNA double-strand breaks. In the current study, sequences in mouse nibrin required to direct the nuclear localization of the MRN complex were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19075003
DOI: 10.1128/MCB.01131-08
PMCID: PMC2643806

Genes

NES
NBN
MRE11
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Nuclear export of NBN is required for normal cellular responses to radiation.PMID 19075003Read ↗

Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.Semantic proximity Read ↗

Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation.Semantic proximity Read ↗

The Nijmegen Breakage Syndrome Protein Is Essential for Mre11 Phosphorylation upon DNA DamageSemantic proximity Read ↗

ATM-dependent phosphorylation of nibrin in response to radiation exposure.Semantic proximity Read ↗

V(D)J rearrangement in Nijmegen breakage syndrome.Semantic proximity Read ↗

Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation.Semantic proximity Read ↗

A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin.Semantic proximity Read ↗

Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN ComplexSemantic proximity Read ↗

The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity.Semantic proximity Read ↗

Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.Semantic proximity Read ↗

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together.Semantic proximity Read ↗

The Mammalian Mre11-Rad50-Nbs1 Protein Complex: Integration of Functions in the Cellular DNA–Damage ResponseSemantic proximity Read ↗

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