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Article

Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Apr 2003

Manning-Bog Amy B, McCormack Alison L, Purisai Maya G, Bolin Laurel M, Di Monte Donato A

Abstract excerpt

Alpha-synuclein is likely to play a role in neurodegenerative processes, including the degeneration of nigrostriatal dopaminergic neurons that underlies Parkinson's disease. However, the toxicological properties of alpha-synuclein remain relatively unknown. Here, the relationship between alpha-synuclein expression and neuronal injury was studied in mice exposed to the herbicide paraquat. Paraquat neurotoxicity...

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Identifiers

PMID: 12716914
PMCID: PMC6742319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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