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Article

Transduced Tat-alpha-synuclein protects against oxidative stress in vitro and in vivo.

Journal of biochemistry and molecular biology - 31 May 2006

Choi Hee Soon, Lee Sun Hwa, Kim So Young, An Jae Jin, Hwang Seok Il, Kim Dae Won, Yoo Ki Yeon, Won Moo Ho, Kang Tae Cheon, Kwon Hyung Joo, Kang Jung Hoon, Cho Sung Woo, Kwon Oh Shin, Choi Jin Hi, Park Jinseu, Eum Won Sik, Choi Soo Young

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative disorder and is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. Although many studies showed that the aggregation of alpha-synuclein might be involved in the pathogenesis of PD, its protective properties against oxidative stress remain to be elucidated. In this study, human wild type and mutant alpha-synuclein genes were...

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PMID: 16756753
DOI: 10.5483/bmbrep.2006.39.3.253

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