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Article

Prognostic and diagnostic relevance of hypermethylated in cancer 1 (HIC1) CpG island methylation in renal cell carcinoma.

International journal of oncology - 1 May 2012

Eggers H, Steffens S, Grosshennig A, Becker J U, Hennenlotter J, Stenzl A, Merseburger A S, Kuczyk M A, Serth J

Abstract excerpt

The tumour suppressor gene hypermethylated in cancer 1 (HIC1) is a transcriptional repressor, which functionally cooperates with p53. Loss of HIC1 function is associated with the development of various tumor entities. The aim of this study was to elucidate the relevance of CpG island (CGI) methylation of HIC1 in renal cell carcinoma (RCC). DNA methylation of HIC1...

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Identifiers

PMID: 22327210
DOI: 10.3892/ijo.2012.1367

Genes

HIC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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