Article
Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution.
The Journal of biological chemistry - 8 Oct 2004
Ciccotosto Giuseppe D, Tew Deborah, Curtain Cyril C, Smith Danielle, Carrington Darryl, Masters Colin L, Bush Ashley I, Cherny Robert A, Cappai Roberto, Barnham Kevin J
Abstract excerpt
The amyloid beta peptide (Abeta) is toxic to neuronal cells, and it is probable that this toxicity is responsible for the progressive cognitive decline associated with Alzheimer's disease. However, the nature of the toxic Abeta species and its precise mechanism of action remain to be determined. It has been reported that the methionine residue at position 35 has a pivotal role to play in the toxicity of Abeta. We...
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