Article

Reactive oxygen species in Alzheimer's disease : studies of amyloid-beta-copper and apolipoprotein E

2019-01-01

Abstract excerpt

There are many hypotheses for the cause of Alzheimer’s disease. This thesis explores one such hypothesis, the metals hypothesis, and attempts to do so from a kinetic point of view. The metals hypothesis posits that Amyloid-b (Ab) can bind intrinsic metals within the brain, causing increased Ab oligomerisation, and (in the case of binding copper or iron) is able to be a source of reactive oxygen species (ROS), via...

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Literature Corpus work: 02790a7e-8040-5b1c-8b4f-fde0481e9d64
DOI: 10.25560/83770

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