Article

Dityrosine cross-link trapping of amyloid-β intermediates reveals that self-assembly is required for Aβ-induced cytotoxicity

2020-03-26

Abstract excerpt

Multiple chemical reactions, such as the production of reactive oxygen species (ROS) can lead to dityrosine (DiY) formation via the cross-linking of closely spaced tyrosine residues and this can serve as a marker for aging. Amyloid-β (Aβ) has been found to be DiY cross-linked in the brains of AD patients. In vitro, Aβ forms DiY cross-links via metal-catalysed oxidation (Cu 2+ and H 2 0 2 ) (MCO) leading to the...

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Literature Corpus work: a45b66b4-9da8-5d2f-9128-75b859c4c57d
DOI: 10.1101/2020.03.25.007690

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