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Article

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.

Science (New York, N.Y.) - 16 Apr 2004

Lustbader Joyce W, Cirilli Maurizio, Lin Chang, Xu Hong Wei, Takuma Kazuhiro, Wang Ning, Caspersen Casper, Chen Xi, Pollak Susan, Chaney Michael, Trinchese Fabrizio, Liu Shumin, Gunn-Moore Frank, Lue Lih-Fen, Walker Douglas G, Kuppusamy Periannan, Zewier Zay L, Arancio Ottavio, Stern David, Yan Shirley ShiDu, Wu Hao

Abstract excerpt

Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD). Here, we demonstrate that Abeta-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Abeta to mitochondrial toxicity. Abeta interacts with ABAD in the mitochondri...

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PMID: 15087549
DOI: 10.1126/science.1091230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15087549-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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