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Article

Rituximab-dependent cytotoxicity by natural killer cells: influence of FCGR3A polymorphism on the concentration-effect relationship.

Cancer research - 1 Jul 2004

Dall'Ozzo Sébastien, Tartas Sophie, Paintaud Gilles, Cartron Guillaume, Colombat Philippe, Bardos Pierre, Watier Hervé, Thibault Gilles

Abstract excerpt

The FCGR3A gene dimorphism generates two allotypes: FcgammaRIIIa-158V and FcgammaRIIIa-158F. The genotype homozygous for FcgammaRIIIa-158V (VV) is associated with higher clinical response to rituximab, a chimeric anti-CD20 IgG1 used in the treatment of B lymphoproliferative malignancies. Our objective was to determine whether this genetic association relates to rituximab-dependent cytotoxicity mediated by...

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Share to Antibodies, Monoclonal
Share to Antibodies, Monoclonal, Murine-Derived

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antibody-Dependent Cell Cytotoxicity

Share to Cells, Cultured

Share to Dose-Response Relationship, Immunologic

Share to Killer Cells, Natural

Share to Receptors, IgG

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Source

Identifiers

PMID: 15231679
DOI: 10.1158/0008-5472.CAN-03-2862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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