Article
Comprehensive genetic and functional analyses of Fc gamma receptors influence on response to rituximab therapy for autoimmunity.
EBioMedicine - 1 Dec 2022
Robinson James I, Md Yusof Md Yuzaiful, Davies Vinny, Wild Dawn, Morgan Michael, Taylor John C, El-Sherbiny Yasser, Morris David L, Liu Lu, Rawstron Andy C, Buch Maya H, Plant Darren, Cordell Heather J, Isaacs John D, Bruce Ian N, Emery Paul, Barton Anne, Vyse Timothy J, Barrett Jennifer H, Vital Edward M, Morgan Ann W
Abstract excerpt
BACKGROUND: Rituximab is widely used to treat autoimmunity but clinical response varies. Efficacy is determined by the efficiency of B-cell depletion, which may depend on various Fc gamma receptor (FcγR)-dependent mechanisms. Study of FcγR is challenging due to the complexity of the FCGR genetic locus. We sought to assess the effect of FCGR variants on clinical response, B-cell depletion and NK-cell-mediated...
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