Article
The FcγRIIIA-158 VV genotype increased the risk of post-transplant lymphoproliferative disorder in T-cell-depleted kidney transplant recipients - a retrospective study.
Transplant international : official journal of the European Society for Organ Transplantation - 1 Aug 2020
Gatault Philippe, Lajoie Laurie, Stojanova Jana, Halimi Jean-Michel, Caillard Sophie, Moyrand Stéphanie, Martinez David, Ladrière Marc, Morelon Emmanuel, Merville Pierre, Essig Marie, Vigneau Cécile, Kamar Nassim, Bouvier Nicolas, Westeel Pierre-François, Mariat Christophe, Hazzan Marc, Thierry Antoine, Etienne Isabelle, Büchler Matthias, Marquet Pierre, Gouilleux-Gruart Valérie, Thibault Gilles
Abstract excerpt
Post-transplantation lymphoproliferative disorder (PTLD) is a severe complication in organ transplant recipients. The use of T lymphocyte-depleting antibodies (TLDAb), especially rabbit TLDAb, contributes to PTLD, and the V158F polymorphism of Fc gamma receptor IIIA (FcγRIIIA) also named CD16A could affect the concentration-effect relationship of TLDAb. We therefore investigated the association of this...
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