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Article

Impact of Fc gamma-receptor polymorphisms on the response to rituximab treatment in children and adolescents with mature B cell lymphoma/leukemia.

Annals of hematology - 1 Sept 2016

Burkhardt Birgit, Yavuz Deniz, Zimmermann Martin, Schieferstein Jutta, Kabickova Edita, Attarbaschi Andishe, Lisfeld Jasmin, Reiter Alfred, Makarova Olga, Worch Jennifer, Bonn Bettina R, Damm-Welk Christine

Abstract excerpt

Recent studies in adult lymphoma patients have indicated a correlation between polymorphisms of Fc gamma-receptors (FcγRs, encoded by the respective FCGR genes) and the response to rituximab treatment. In vitro, cells expressing FcγRIIIa-158V mediate antibody-dependent cellular cytotoxicity (ADCC) more efficiently than cells expressing FcγRIIIa-158F. The impact of the FCGR2A-131HR polymorphism is unclear. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27376362
DOI: 10.1007/s00277-016-2731-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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