Article
Single nucleotide polymorphisms in protein tyrosine phosphatase 1beta (PTPN1) are associated with essential hypertension and obesity.
Human molecular genetics - 1 Sept 2004
Olivier Michael, Hsiung Chao A, Chuang Lee-Ming, Ho Lo-Tone, Ting Chih-Tai, Bustos Valerie I, Lee Teresa M, De Witte Anniek, Chen Yii-Der I, Olshen Richard, Rodriguez Beatriz, Wen Chi-Chung, Cox David R
Abstract excerpt
Protein tyrosine phosphatase 1beta (PTP-1beta) is involved in the regulation of several important physiological pathways. It regulates both insulin and leptin signaling, and interacts with the epidermal- and platelet-derived growth factor receptors. The gene is located on human chromosome 20q13, and several rare single nucleotide polymorphisms (SNPs) have been shown to be associated with insulin resistance and...
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