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Article

Protein tyrosine phosphatase 1B gene polymorphisms and essential hypertension: a case-control study in Chinese population.

Journal of endocrinological investigation - 1 Jan 2000

Gu P, Jiang W, Du H, Shao J, Lu B, Wang J, Zou D

Abstract excerpt

BACKGROUND: Protein tyrosine phosphatase (PTP)- 1B, encoded by the PTPN1 gene, negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor kinase activation segment. Several rare single nucleotide polymorphisms (SNP) have been linked to diseases accompanying insulin resistance such as Type 2 diabetes, obesity, and dyslipidemia in different populations. AIM: To...

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Source

Identifiers

PMID: 20101100
DOI: 10.1007/BF03346629

Genes

PTPN1

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