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Article

Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population.

BMC medical genetics - 5 May 2006

Cheyssac Claire, Lecoeur Cécile, Dechaume Aurélie, Bibi Amina, Charpentier Guillaume, Balkau Beverley, Marre Michel, Froguel Philippe, Gibson Fernando, Vaxillaire Martine

Abstract excerpt

BACKGROUND: The protein tyrosine phosphatase-1B, a negative regulator for insulin and leptin signalling, potentially modulates glucose and energy homeostasis. PTP1B is encoded by the PTPN1 gene located on chromosome 20q13 showing linkage with type 2 diabetes (T2D) in several populations. PTPN1 gene variants have been inconsistently associated with T2D, and the aim of our study was to investigate the effect of...

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Identifiers

PMID: 16677372
DOI: 10.1186/1471-2350-7-44
PMCID: PMC1525165

Genes

PTPN1

Variants

Provenance

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