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Article

Association of protein tyrosine phosphatase 1B gene polymorphisms with type 2 diabetes.

Diabetes - 1 Nov 2004

Bento Jennifer L, Palmer Nicholette D, Mychaleckyj Josyf C, Lange Leslie A, Langefeld Carl D, Rich Stephen S, Freedman Barry I, Bowden Donald W

Abstract excerpt

The PTPN1 gene codes for protein tyrosine phosphatase 1B (PTP1B) (EC 3.1.3.48), which negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor kinase activation segment. PTPN1 is located in 20q13, a genomic region linked to type 2 diabetes in multiple genetic studies. Surveys of the gene have previously identified only a few uncommon coding single nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

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Source

Identifiers

PMID: 15504984
DOI: 10.2337/diabetes.53.11.3007

Genes

PTPN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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