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Article

PTPN1 polymorphisms are associated with total and low-density lipoprotein cholesterol.

European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology - 1 Feb 2010

Bauer Florianne, Onland-Moret N Charlotte, Charlotte Onland-Moret N, Niehoff Anne G, Elbers Clara C, Grobbee Diederick E, Wijmenga Cisca, van der Schouw Yvonne T

Abstract excerpt

BACKGROUND: The protein tyrosine phosphatase nonreceptor type 1 (PTPN1) gene encodes for the protein tyrosine phosphatase 1B, which suppresses the signaling pathway of insulin. Variations in PTPN1 may lead to changes in insulin sensitivity and consequent changes in protein tyrosine phosphatase 1B activity may also contribute to the development of metabolic endophenotypes. Our aim was to investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20177231
DOI: 10.1097/HJR.0b013e32832d30c4

Genes

PTPN1

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