Article
A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in Oji-Cree.
The Journal of clinical endocrinology and metabolism - 1 Feb 2002
Mok Andrea, Cao Henian, Zinman Bernard, Hanley Anthony J G, Harris Stewart B, Kennedy Brian P, Hegele Robert A
Abstract excerpt
Several lines of evidence support a role for protein tyrosine phosphatase 1B (PTP-1B) in metabolism, and specifically in insulin sensitivity and obesity. We report the development of reagents for the amplification and sequencing of the PTP-1B gene, which has resulted in the identification of a novel single nucleotide polymorphism (SNP), designated 981C-->T. We found a significant association between this SNP and...
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