Article
Polymorphisms within the protein tyrosine phosphatase 1B (PTPN1) gene promoter: functional characterization and association with type 2 diabetes and related metabolic traits.
Clinical chemistry - 1 Sept 2007
Meshkani Reza, Taghikhani Mohammad, Al-Kateb Hussam, Larijani Bagher, Khatami Shohreh, Sidiropoulos Gus Konstantinos, Hegele Robert Alexander, Adeli Khosrow
Abstract excerpt
BACKGROUND: Protein tyrosine phosphatase 1B (PTPN1) dephosphorylates insulin receptors and attenuates insulin signaling. Polymorphisms in the coding sequence of PTPN1 have been variably associated with type 2 diabetes (T2D). We hypothesized that variations within the PTPN1 promoter might contribute to the development of T2D and related metabolic traits. METHODS: We screened 2.0 kb of PTPN1 promoter in 174 T2D...
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