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Article

1484insG polymorphism of the PTPN1 gene is associated with insulin resistance in an Iranian population.

Archives of medical research - 1 Jul 2007

Meshkani Reza, Taghikhani Mohammad, Mosapour Abbas, Larijani Bagher, Khatami Shohreh, Khoshbin Ehteram, Ahmadvand Davood, Saeidi Parinaz, Maleki Ali, Yavari Kamal, Nasoohi Nikoo, Adeli Khosrow

Abstract excerpt

BACKGROUND: Protein tyrosine phosphatase 1B (PTP1B), encoded by the PTPN1 gene, efficiently dephosphorylates the insulin receptor, and attenuates insulin signaling. Recently, a 1484insG variant of the PTPN1 gene has been associated with an increased risk of metabolic syndrome in an Italian population that has not been confirmed in the subsequent studies. The purpose of this study was to investigate the...

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Share to Diabetes Mellitus, Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Restriction Fragment Length

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

Share to Protein Tyrosine Phosphatases

Source

Identifiers

PMID: 17560463
DOI: 10.1016/j.arcmed.2007.01.010

Genes

PTPN1

Provenance

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