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Post-Transcriptional Regulation of Immune Responses and Inflammatory Diseases by RNA-Binding ZFP36 Family Proteins.

Frontiers in immunology - 1 Jan 2021

Makita Sohei, Takatori Hiroaki, Nakajima Hiroshi

Abstract excerpt

Post-transcriptional regulation is involved in the regulation of many inflammatory genes. Zinc finger protein 36 (ZFP36) family proteins are RNA-binding proteins involved in messenger RNA (mRNA) metabolism pathways. The ZFP36 family is composed of ZFP36 (also known as tristetraprolin, TTP), ZFP36L1, ZFP36L2, and ZFP36L3 (only in rodents). The ZFP36 family proteins contain two tandemly repeated CCCH-type...

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PMID: 34276705
DOI: 10.3389/fimmu.2021.711633
PMCID: PMC8282349

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