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Article

The copper transporter CTR1 provides an essential function in mammalian embryonic development.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jun 2001

Kuo Y M, Zhou B, Cosco D, Gitschier J

Abstract excerpt

Copper serves as an essential cofactor for a variety of proteins in all living organisms. Previously, we described a human gene (CTR1;SLC31A1) that encodes a high-affinity copper-uptake protein and hypothesized that this protein is required for copper delivery to mammalian cells. Here, we test this hypothesis by inactivating the Ctr1 gene in mice by targeted mutagenesis. We observe early embryonic lethality in...

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Identifiers

PMID: 11391004
DOI: 10.1073/pnas.111057298
PMCID: PMC34439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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