Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface.

Journal of molecular biology - 5 Sept 1992

Tulip W R, Varghese J N, Webster R G, Laver W G, Colman P M

Abstract excerpt

The site on influenza virus N9 neuraminidase recognized by NC41 monoclonal antibody comprises 19 amino acid residues that are in direct contact with 17 residues on the antibody. Single sequence changes in some of the neuraminidase residues in the site markedly reduce antibody binding. However, tw...

Topics

Antibodies, Monoclonal
Antibodies, Viral
Antigen-Antibody Complex
Antigens, Viral
Crystallography
Immunoglobulin Fab Fragments
Influenza A virus
Models, Molecular
Mutation
Neuraminidase
Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

Structure-Activity Relationship

X-Ray Diffraction

Source

Identifiers

PMID: 1522584
DOI: 10.1016/0022-2836(92)90688-g

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1522584-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface.PMID 1522584Read ↗

N9 neuraminidase complexes with antibodies NC41 and NC10: empirical free energy calculations capture specificity trends observed with mutant binding data.Semantic proximity Read ↗

Antigenicity of the N8 influenza A virus neuraminidase: existence of an epitope at the subunit interface of the neuraminidase.Semantic proximity Read ↗

Single-amino-acid mutation in the HA alters the recognition of H9N2 influenza virus by a monoclonal antibody.Semantic proximity Read ↗

Mechanism of antigenic variation in an individual epitope on influenza virus N9 neuraminidase.Semantic proximity Read ↗

Structural consequences of target epitope-directed functional alteration of an antibody. The case of anti-hen lysozyme antibody, HyHEL-10.Semantic proximity Read ↗

Antigenic, sequence, and crystal variation in influenza B neuraminidase.Semantic proximity Read ↗

Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98).Semantic proximity Read ↗

An Epidemiologically Significant Epitope of a 1998 Human Influenza Virus Neuraminidase Forms a Highly Hydrated Interface in the NA–Antibody ComplexSemantic proximity Read ↗

Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.Semantic proximity Read ↗

Epitope mapping in cell surface proteins by site-directed masking: defining the structural elements of NTPDase3 inhibition by a monoclonal antibody.Semantic proximity Read ↗

Rigid-body docking with mutant constraints of influenza hemagglutinin with antibody HC19.Semantic proximity Read ↗

Crystal structure of a cross-reaction complex between Fab F9.13.7 and guinea fowl lysozyme.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.