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Article

Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface.

Journal of molecular biology - 5 Sept 1992

Tulip W R, Varghese J N, Webster R G, Laver W G, Colman P M

Abstract excerpt

The site on influenza virus N9 neuraminidase recognized by NC41 monoclonal antibody comprises 19 amino acid residues that are in direct contact with 17 residues on the antibody. Single sequence changes in some of the neuraminidase residues in the site markedly reduce antibody binding. However, two mutants have been found within the site, Ile368 to Arg and Asn329 to Asp selected by antibodies other than NC41, and...

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Source

Identifiers

PMID: 1522584
DOI: 10.1016/0022-2836(92)90688-g

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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