Article
N9 neuraminidase complexes with antibodies NC41 and NC10: empirical free energy calculations capture specificity trends observed with mutant binding data.
Biochemistry - 5 Jul 1994
Tulip W R, Harley V R, Webster R G, Novotny J
Abstract excerpt
X-ray crystallographic coordinates of influenza virus N9 neuraminidase complexed with monoclonal antibodies NC41 and NC10 [Tulip et al. (1992) J. Mol. Biol. 227, 122-148] served as a starting point for calculations aimed at estimating free energy changes (delta G) of complex formation between the...
Topics
- Antibodies, Monoclonal
- Antibodies, Viral
- Antigen-Antibody Complex
- Crystallography, X-Ray
- Epitopes
- Immunoglobulin Fab Fragments
- Models, Molecular
- Motion
- Mutation
- Neuraminidase
- Orthomyxoviridae
- Protein Binding
- Solvents
- Surface Properties
- Thermodynamics