Article
Crystal structure of a cross-reaction complex between Fab F9.13.7 and guinea fowl lysozyme.
The Journal of biological chemistry - 28 Jul 1995
Lescar J, Pellegrini M, Souchon H, Tello D, Poljak R J, Peterson N, Greene M, Alzari P M
Abstract excerpt
The crystal structure of the complex between the cross-reacting antigen Guinea fowl lysozyme and the Fab from monoclonal antibody F9.13.7, raised against hen egg lysozyme, has been determined by x-ray diffraction to 3-A resolution. The antibody interacts with exposed residues of an alpha-helix and surrounding loops adjacent to the lysozyme active site cleft. The epitope of lysozyme bound by antibody F9.13.7...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Base Sequence
- Birds
- Cross Reactions
- Crystallography, X-Ray
- DNA
- Immunoglobulin Fab Fragments
- Immunoglobulin Variable Region
- Macromolecular Substances