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Article

Structural consequences of target epitope-directed functional alteration of an antibody. The case of anti-hen lysozyme antibody, HyHEL-10.

The Journal of biological chemistry - 4 Jul 2003

Kumagai Izumi, Nishimiya Yoshiyuki, Kondo Hidemasa, Tsumoto Kouhei

Abstract excerpt

Decreased affinity of an antibody for a mutated epitope in an antigen can be enhanced and reversed by mutations in certain antibody residues. Here we describe the crystal structures of (a) the complex between a naturally mutated proteinaceous antigen and an antibody that was mutated and selected in vitro, and (b) the complex between the normal antigen and the mutated antibody. The mutated and selected antibody...

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Source

Identifiers

PMID: 12709438
DOI: 10.1074/jbc.M301149200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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