Article
Rigid-body docking with mutant constraints of influenza hemagglutinin with antibody HC19.
Proteins - 1 Jan 1994
Cherfils J, Bizebard T, Knossow M, Janin J
Abstract excerpt
An automatic docking algorithm has been applied to the modeling of the complex between hemagglutinin from influenza virus and the Fab fragment of a monoclonal antibody raised against this antigen. We have introduced here the use of biochemical information provided by mutants of hemagglutinin. The...
Topics
- Algorithms
- Amino Acid Sequence
- Antigen-Antibody Complex
- Antigen-Antibody Reactions
- Computer Simulation
- Epitopes
- Hemagglutination, Viral
- Hemagglutinin Glycoproteins, Influenza Virus
- Hemagglutinins, Viral
- Hydrogen Bonding
- Immunoglobulin Fab Fragments
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Selection, Genetic