Article
Rigid-body docking with mutant constraints of influenza hemagglutinin with antibody HC19.
Proteins - 1 Jan 1994
Cherfils J, Bizebard T, Knossow M, Janin J
Abstract excerpt
An automatic docking algorithm has been applied to the modeling of the complex between hemagglutinin from influenza virus and the Fab fragment of a monoclonal antibody raised against this antigen. We have introduced here the use of biochemical information provided by mutants of hemagglutinin. The docking procedure finds a small number of candidate solutions where three sites of escape mutations are buried and...
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