Mechanism of antigenic variation in an individual epitope on influenza virus N9 neuraminidase.

doi:10.1128/JVI.64.12.5797-5803.1990

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Article

Mechanism of antigenic variation in an individual epitope on influenza virus N9 neuraminidase.

Journal of virology - 1 Dec 1990

Air G M, Laver W G, Webster R G

Abstract excerpt

Monoclonal antibodies which inhibit influenza virus neuraminidase (NA) and which therefore indirectly neutralize virus infectivity bind to epitopes located on the rim of the active-site crater. The three-dimensional structure of one of these epitopes, recognized by monoclonal antibody NC41, has p...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antigenic Variation
Cell Line
Epitopes
Immunodiffusion
Influenza A virus
Models, Molecular
Molecular Sequence Data
Mutation
Neuraminidase
Protein Conformation
RNA, Viral

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