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Article

Antigenicity of the N8 influenza A virus neuraminidase: existence of an epitope at the subunit interface of the neuraminidase.

Journal of virology - 1 Mar 1994

Saito T, Taylor G, Laver W G, Kawaoka Y, Webster R G

Abstract excerpt

To locate antigenic epitopes on the N8 neuraminidase (NA), we generated a panel of 97 monoclonal antibodies (MAbs), 66 of which inhibited NA activity (NI antibodies). Three groups of NI MAbs were identified from their different reactivities with escape mutants. Group 1 antibodies recognized the peptide loop containing residues 344 to 346, which appears to be an immunodominant region on the rim of the enzyme...

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Identifiers

PMID: 7509002
DOI: 10.1128/JVI.68.3.1790-1796.1994
PMCID: PMC236640

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Source receipt: pubmed, retrieved 7 Sept 2026.

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