Article
Antigenicity of the N8 influenza A virus neuraminidase: existence of an epitope at the subunit interface of the neuraminidase.
Journal of virology - 1 Mar 1994
Saito T, Taylor G, Laver W G, Kawaoka Y, Webster R G
Abstract excerpt
To locate antigenic epitopes on the N8 neuraminidase (NA), we generated a panel of 97 monoclonal antibodies (MAbs), 66 of which inhibited NA activity (NI antibodies). Three groups of NI MAbs were identified from their different reactivities with escape mutants. Group 1 antibodies recognized the peptide loop containing residues 344 to 346, which appears to be an immunodominant region on the rim of the enzyme...
Topics
- Amidohydrolases
- Antibodies, Monoclonal
- Antibodies, Viral
- Base Sequence
- Epitopes
- Influenza A virus
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Neuraminidase
- Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase