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Article

Single-amino-acid mutation in the HA alters the recognition of H9N2 influenza virus by a monoclonal antibody.

Biochemical and biophysical research communications - 20 Jun 2008

Ping Jihui, Li Chengjun, Deng Guohua, Jiang Yongping, Tian Guobin, Zhang Shuxia, Bu Zhigao, Chen Hualan

Abstract excerpt

We explored the molecular basis of antigenic variation by comparing two H9N2 subtype avian influenza viruses, A/Chicken/Shandong/6/96 (CK/SD/6) and A/Chicken/Guangxi/10/99 (CK/GX/10), that react differently to a monoclonal antibody C/B3. To assess the genetic basis for this antigenic difference, we used reverse genetics to generate a series of chimera and mutants of these two viruses. We found that a...

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Identifiers

PMID: 18424263
DOI: 10.1016/j.bbrc.2008.04.045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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